Stable maintenance of genetic information during meiosis and mitosis is dependent on accurate chromosome transmission. The centromere is a key component of the segregational machinery that couples chromosomes with the spindle apparatus. Most of what is known about the structure and function of the centromeres has been derived from studies on yeast cells. In Saccharomyces cerevisiae, the centromere DNA requirements for mitotic centromere function have been defined and some of the proteins required for an active complex have been identified. Centromere (...) DNA and the centromere proteins form a complex that has been studied extensively at the chromatin level. Finally, recent findings suggest that assembly and activation of the centromere are integrated in tethe cell cycle. (shrink)

The Y chromosomes of most Drosophila species are necessary for male fertility but they are not involved in sex determination. They have many puzzling properties that resemble the effects caused by B chromosomes. Classical genetic and molecular studies reveal substantial affinities between Y and B chromosomes and suggest that the Y chromosomes of Drosophila are not degenerated homologues of the X chromosomes, but rather that their Y chromosomes evolved as specialized supernumeraries similar to classical B chromosomes.

During the last decade, Network Science has become one of the most active fields in applied physics and mathematics, since it allows the analysis of a diversity of social, biological and technological systems [24]. From the diversity of applications of Network Science, in this Opinion paper we are concerned about its potential to analyse one of the most extended group sports, Football (soccer in U.S. terminology) [29], since it allows addressing different aspects of the team organization and performance not captured (...) by classical analyses based on the performance of individual players. The reason behind relies on the complex nature of the game, which, paraphrasing the foundational paradigm of complexity sciences “can not be analysed by looking at its components (i.e., players) individually but, on the contrary, considering the system as a whole” or, in the classical words of after-match interviews “it’s not just me, it’s the team”. The recent ability of obtaining datasets of all events occurring during a match, including the position of the players and the interactions between them has opened the door to new kind of studies where it is possible to analyse and quantify the behaviour of a team as a whole, together with the role of a single player [17]. Under this framework, the organization of a team can be considered as the result of the interaction between its players, creating a network based on passes. In this way, we can create passing networks, which are directed (i.e.,... (shrink)

Peer review is a widely accepted instrument for raising the quality of science. Peer review limits the enormous unstructured influx of information and the sheer amount of dubious data, which in its absence would plunge science into chaos. In particular, peer review offers the benefit of eliminating papers that suffer from poor craftsmanship or methodological shortcomings, especially in the experimental sciences. However, we believe that peer review is not always appropriate for the evaluation of controversial hypothetical science. We argue that (...) the process of peer review can be prone to bias towards ideas that affirm the prior convictions of reviewers and against innovation and radical new ideas. Innovative hypotheses are thus highly vulnerable to being “filtered out” or made to accord with conventional wisdom by the peer review process. Consequently, having introduced peer review, the Elsevier journal Medical Hypotheses may be unable to continue its tradition as a radical journal allowing discussion of improbable or unconventional ideas. Hence we conclude by asking the publisher to consider re-introducing the system of editorial review to Medical Hypotheses. (shrink)

En filosofisk hermeneutik -- Hvad værdibegrebet duer til og ikke duer til -- Videnskab og kritik -- Videnskab og ideologi -- Ideologi og sandhed -- Naturdialektik som bidrag til en ædruelig kritik af den instrumentelle fornuft? -- Humanistisk videnskabsteori i en tværfaglig tid -- Hermeneutisk rationalitet -- Habermas versus Krovoza -- Løgstrups sprogfilosofi i dagens kontekst.

The rapid expansion of research on Brain-Computer Interfaces is not only due to the promising solutions offered for persons with physical impairments. There is also a heightened need for understanding BCIs due to the challenges regarding ethics presented by new technology, especially in its impact on the relationship between man and machine. Here we endeavor to present a scoping review of current studies in the field to gain insight into the complexity of BCI use. By examining studies related to BCIs (...) that employ social research methods, we seek to demonstrate the multitude of approaches and concerns from various angles in considering the social and human impact of BCI technology. For this scoping review of research on BCIs’ social and ethical implications, we systematically analyzed six databases, encompassing the fields of medicine, psychology, and the social sciences, in order to identify empirical studies on BCIs. The search yielded 73 publications that employ quantitative, qualitative, or mixed methods. Of the 73 publications, 71 studies address the user perspective. Some studies extend to consideration of other BCI stakeholders such as medical technology experts, caregivers, or health care professionals. The majority of the studies employ quantitative methods. Recurring themes across the studies examined were general user opinion towards BCI, central technical or social issues reported, requests/demands made by users of the technology, the potential/future of BCIs, and ethical aspects of BCIs. Our findings indicate that while technical aspects of BCIs such as usability or feasibility are being studied extensively, comparatively little in-depth research has been done on the self-image and self-experience of the BCI user. In general there is also a lack of focus or examination of the caregiver’s perspective. (shrink)

The ground-state dispersion energy of a pair of axially symmetric molecules is calculated, to arbitrary order in the inverse intermolecular separation, on the basis of London's anisotropic oscillator model.

A study is made of the dominant terms of an earlier model-based formula describing the dispersion energy of axially symmetric interacting molecules. The existence of mixed-pole eighth-order terms is noted.

After a brief sketch of the state of Buridan studies, this review article examines the recent study, by Benoît Patar, of a commentary on Aristotle’s Physics that is generally attributed to Albert of Saxony, but which Patar believes to have been authored by John Buridan (the text is preserved in the manuscript Bruges, Stadsbibliotheek 477, fols. 60va–163vb, and was edited by Patar himself in 1999). Patar is utterly convinced that the Bruges Quaestiones represent Buridan’s prima lectura, that is, his first (...) course of lectures on the Physics, which preceded the two other redactions that are traditionally attributed to him. However, there is no textual evidence in support of this assumption, but only speculative circumstantial evidence. The article therefore rejects Patar’s thesis as highly problematic. (shrink)